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Center for Pain Research and Innovation




A Study of Muscle, Joint, Jaw Function, and Related Persistent Pain Conditions

What is TMD? TMD refers to Temporomandibular Disorders, a set of conditions affecting the jaw joint and/or muscles.  Signs may include pain, limited mobility and function, and jaw joint noise.  The OPPERA II Study aims to provide valuable new information about the causes of TMD and related painful disorders. This study may also help researchers identify new treatments for TMD.

Who can enroll in OPPERA-II?  If you are between 18 - 74 years old and in good health you may be eligible to participate in this important study.  You should not have kidney disease requiring dialysis or uncontrolled heart disease, respiratory disease, or hypertension.  You should not have epilepsy, diabetes (unless controlled with medication/diet), or have been hospitalized for a psychiatric condition in the last 6 months.  Your current health will be discussed in more detail via a telephone screening. 

There are two study pathways in OPPERA-II; if you are eligible, you will complete only one:

Pathway One (UNC IRB Study #13-2232)
Participants provide a self-collected saliva sample and complete one questionnaire at home or online.  They receive a packet of materials from us by mail along with a postage-paid envelope to return completed items.  Participants receive $25 for completing all study activities.  

Pathway Two (UNC IRB Study #13-0780)
Participants complete questionnaires at home or online and undergo one 3-hour clinic visit consisting of a medical history, questionnaires, examination of muscles and joints, and tests of reactions to pressure and heat.  Participants also provide a small sample of blood. Over the next year, participants complete 4 health questionnaires from home or online, then return for a second clinic visit.  Participants receive up to $240 for completing all study activities.

How can you help?  By calling or emailing our researchers for more information on how you can volunteer to be a part of this  important study. Contact us at: 1-877-810-9530 #503 or by email:

Last Modified: 02/20/2014