Research - Clinical Studies
Clinical Study Title
A molecular and cellular comparison of bone inductive properties of trabecular metal® vs. titanium among Healthy, diabetic and osteopenic subjects
Description/Purpose of the Study
Certain environmental and systemic conditions affect wound healing after dental implant surgery. After your body undergoes a surgery, a series of events is triggered to promote wound healing. Human studies have demonstrated that for the same type and extent of wound, some people can heal faster and have fewer complications. The purpose of this research study is to investigate whether genetic changes will show advantageous wound healing differences between two different metals (Trabecular vs. Titanium), traditionally used for implants. In addition, we are interested in determining whether these genetic expressions will show which of these two metals promotes healing best when used in patients that have diabetes or osteoporosis.
|IRB Study #:||11-2539|
|Principal Investigator:||Steven Offenbacher, DDS, PhD, MMSc|
You may be eligible to participate if you are:
Generally healthy or have diabetes or have osteoporosis
Have already been approved and treatment planned for implant surgery by someone other than study-personnel.
You should not be in this study if you:
Have chronic disease with oral manifestations.
Have used antibiotics (e.g. amoxicillin, clindamycin, tetracycline and erythromycin) or have been chronically using Non-Steroidal Anti-Inflammatory Drugs (e.g. aspirin, ibuprofen and naproxen) within the last month.
Require pre-medication antibiotics prior to dental treatment.
Have received any medications known to affect periodontal status within the last month. For example: Arestin, PerioChip, doxycycline.
Have ever used intravenous (iv) bisphosphonates.
Have HIV or infectious diseases such as hepatitis or tuberculosis.
Are planning to become pregnant within the next 3 months, currently pregnant or nursing.
If you of clench or grind your teeth.
Have blood disorders or are taking blood thinners (Unless you can provide a International Normaized Ratio INR showing a value of 0.8-2.0).
Are taking any therapy or medication such as high dose steroids, radiation therapy or chemotherapy.
Are allergic to topical or local anesthesia.