About Our School

Dentin and Bone Biology Research

Miguez, Patricia, DDS, PhD_Oper_4x6

Dr. Patricia Miguez Assistant Professor Dentin and Bone Biology Research Director

Currently there is a gap of knowledge in that we have not been able to identify a reliable form of preventing dentin and bone loss in various physiological and pathological scenarios. Our long-term goals are to unveil novel mechanisms of protecting such mineralized tissues, characterize new effective agents and ultimately bring these agents to clinical practice. Our research studies have concentrated in understanding collagen biochemistry and tissue mechanical properties link; promotion of mineralization (re-mineralization) in dentin and bone and, the role of the proteoglycan biglycan and glycosaminoglycans in promotion of craniofacial bone regeneration through modulation of bone morphogenetic protein function. More recently, we’ve engaged in exploring organic compounds and carbohydrates in modulation of mineralization. Another area of interest is on integrative medicine where we seek to understand how natural compounds (phytochemicals) act on cell behavior, extracellular matrix quality and mineralization as well as their effect on oral diseases development such as caries and periodontal disease.

 

Ongoing Projects

  • Biglycan on bone biology.
  • Proteoglycans on dentin bonding.
  • Phytochemicals on bone regeneration.
  • Prevention and treatment of erosion via chitosan-based therapy.
  • Synthetic Carbohydrates in bone maintenance.
  • NO-releasing polymer and diabetic bone maintenance.
  • mREG knock out mouse phenotype characterization and behavior in infection.
  • Dentin repair and/or regeneration by dental materials and a newly developed biomaterial.

 

Recent Publications

  • Reside J, Everett E, Padilla R, Arce R, Miguez P, Brodala N, DeKok I, Nares S. In vivo assessment of bone healing following Piezotome® ultrasonic instrumentation. Clin Implant Dent Relat Res 2015;17:384-394
  • Nagaoka H, Nagaoka H, Walter R, Boushell LW, Miguez PA, Burton A, Ritter AV, Yamauchi M. Characterization of genipin-modified dentin collagen. Biomed Res International 2014 [doi: 10.1155/2014/702821].
  • Miguez PA, Terajima M, Nagaoka H, Ferreira J, Braswell K, Ko C, Yamauchi M. Recombinant biglycan promotes bone morphogenetic protein-induced osteogenesis in vitro and in vivo. Journal of Dental Research 2014 [doi:  1177/0022034514521237].

 

List of published work (Miguez PA)